Neuroendocrine refers to interactions between the nervous system and the endocrine system. Muscle growth and strength increase largely depend on the neuroendocrine adaptations and acute responses evoked during exercise.
Unfortunately, one of the critical elements missing from isolation ‘weight-training’ movements (ex. bicep curls) is they invoke essentially no Neuroendocrine response.
A vital hormonal response to athletic development is a substantial testosterone increase, along with an insulin-like growth factor and human growth hormone. Exercising with protocols known to elevate these hormones eerily mimics the hormonal changes sought in exogenous hormonal therapy (steroid use). Training Programs that induce a high neuroendocrine response produce top tier athletes. Increased muscle mass and bone density are just two of many adaptive responses to exercises capable of producing a significant Neuro. response.
A starting point recommended for ‘weightlifting’ would be mastering ‘powerlifting’
(the sport of three lifts: the Bench Press, Squat and Deadlift) to be followed later by the more dynamic ‘Clean’, ‘Jerk’, the ‘Clean & Jerk’ and the ‘Snatch’. Being not only demanding of precision and athleticism, these multi-joint compounds elicit a profound Neuroendocrine response, emphasizing constant engagement of midline, working core to extremities.
Simply put, in order to maximize neuroendocrine response focus on working large muscle groups before smaller muscle groups. Use higher volume and moderate to high intensity with shorter rest intervals between sets.
If you are not an avid Olympic Weightlifter, activate a higher Neuro. response, by programming your smaller muscle groups with your largest muscle groups. (ex. Superset your Bicep Curls with DeadLifts, your Tricep Extensions with Bench Press, Shoulder Laterals with Squats). Recruit an even larger response by incorporating Compound movements (ex. a Front Squat with an Overhead Press, a Sumo Deadlift with an Upright Row, a Back Squat with a wide grip Behind the neck Press).
Maximize you Natural Growth Hormone by recruiting more muscle fibers, more quickly and more intensely.